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December 31, 2021

If you are taking the drug Cialis on your own, an overdose is quite possible. If side effects occur when taking a large dose of tadalafil, then you can try to flush the stomach. This action will be effective if no more than 30 minutes or a maximum of 1 hour have passed after taking the drug, otherwise, the active substance will have time to completely penetrate into the blood.

December 22, 2021

In case of severe manifestations of adverse effects, an urgent need to consult a doctor. The drug can reduce or increase blood pressure, affect the work of the heart, and cause priapism. You cannot solve such problems on your own; it is better to trust medical professionals. Film-coated tablets of light yellow color, almond-shaped, engraved "C 5" on one side.

December 13, 2021

Excipients: lactose monohydrate - 109.65 mg, lactose monohydrate (spray dried) - 17.50 mg, hyprolose - 1.22 mg, hyprolose (extra fine) - 2.80 mg, sodium lauryl sulfate - 0.49 mg, microcrystalline cellulose - 26.25 mg, croscarmellose sodium - 11.20 mg , magnesium stearate (vegetable) - 0.88 mg. The composition of the film shell: yellow opadry (Y-30-12863-A) - 8.75 mg (lactose monohydrate - 3.72 mg, hypromellose - 2.59 mg, titanium dioxide - 1.54 mg, triacetin - 0.74 mg, iron dye yellow oxide - 0.16 mg).

December 4, 2021
An agent for the treatment of erectile dysfunction, is a reversible selective inhibitor of specific PDE5 cGMP. When sexual arousal induces a local release of nitric oxide, inhibition of PDE5 by tadalafil leads to an increase in cGMP levels in the corpus cavernosum of the penis. The consequence of this is relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

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In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the corpora cavernosa, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, and cerebellum.

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In addition, tadalafil is approximately 700 times more active against PDE5 than against PDE6, which is found in the retina and is responsible for phototransmission. Tadalafil is also 10,000 times more active against PDE5 compared to its effect on PDE7-PDE10. Acts within 36 hours. The effect appears within 16 minutes after ingestion in the presence of sexual arousal.

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  • Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic pressure, compared with placebo in the supine position (the average maximum decrease is 1.6 / 0.8 mm Hg, respectively) and standing (the average maximum decrease is 0.2 / 4.6 mm Hg). respectively). Tadalafil does not cause a significant change in heart rate.
  • Tadalafil does not cause changes in color recognition (blue / green), which is explained by its low affinity for PDE6. In addition, there is no observed effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size.
  • There was no clinically significant effect on sperm characteristics in men who took tadalafil in daily doses for 6 months. Cialis - instructions for use, mechanism of action, indications, form of release, composition and price. According to the medical classification, Cialis is a remedy for improving erectile dysfunction.and functions. Its active ingredient tadalafil treats disorders in which a man cannot achieve and maintain an erection for intercourse. The drug is produced by English, Dutch and Swiss companies. Check out its instructions for use.